Light Emitting Diode Mediated Photobiomodulation Therapy in Orthodontics – A Review of Contemporary Literature

Light Emitting Diode Mediated Photobiomodulation Therapy in Orthodontics – A Review of Contemporary Literature

Apr 06, 2023
pbmadmin
Orthodontics

BACKGROUND
Photobiomodulation is an emerging area of medical and dental science that has gained attention in numerous clinical fields with the advent of new generational light – emitting diodes (LEDs), as evident in the extent of published scientific literature in recent years. The rationale behind LED – mediated photobiomodulation therapy (LPT) is that at certain biologically active wavelengths, LEDs have shown to have therapeutic effects at the cellular and subcellular levels and are an efficient alternative photon source after lasers, along with their numerous benefits.
Subsequent to favourable in-vitro, animal and recently human clinical trials, considerable attention has been garnered towards the promising applications and the integration of LPT with traditional therapeutic protocols, including in orthodontics. Originally started and accepted as a modality in acceleration of tooth movement, pain management and increasing the bone remodelling rate and quality, the advancements in this therapeutic technology have created new avenues in the treatment of temporomandibular disorders, root resorption, bone consolidation during maxillary expansion and distraction osteogenesis, as well as for improvement in miniscrew stability. Since it is non-invasive, easy to perform and user friendly with reported efficacy, an established consensus of wavelengths and parameters with respect to guidance for clinical use will go a long way in enabling the successful achievement of numerous objectives. This review article of published research intends to evaluate the adjunctive applications of LPT within orthodontic treatment at several levels along with the underlying mechanism, parameters and reported outcomes.

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Dr Michael R Hamblin

Science and Research Advisor

Michael R Hamblin Ph.D. was a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School for 25 years, and is now a Distinguished Visiting Professor at the University of Johannesburg, South Africa and affiliated faculty at Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.

He gained his PhD in organic chemistry from Nottingham Trent University in England. His research interests include photodynamic therapy, photobiomodulation, drug delivery, nanomedicine, and tissue engineering. His research program was supported by NIH, CDMRP, USAFOSR and CIMIT.

He has published over 750 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 10 patents. He is Editor-in-Chief of “Photobiomodulation, Photomedicine and Laser Surgery”, Associate Editor for 10 journals, on the editorial board of a further 60 journals. He has an h-factor 148 and > 88,000 citations. He has authored/edited 36 textbooks on PDT, photomedicine, and nanomedicine including 13 SPIE proceedings.

Dr Hamblin was elected as a Fellow of SPIE in 2011, received the 1st Endre Mester Lifetime Achievement Award from NAALT in 2017, the Outstanding Career Award from the Dose Response Society, the 1st Ali Javan award for Photobiomodulation Basic Science Research from WALT in 2018, and the Lifetime Achievement Award from European Medical Laser Association in 2022.

PBM WHITE

A WHITE SMILE IS NOTHING SHORT OF A CONFIDENT SMILE

  • PBM White embraces the use of light technology to whitening smiles. Our unique gel removes years of stains caused by coffee, tea, wine, or smoking.
  • PBM White combines a unique 2 wave lengths technology and a proprietary gel formulation to  allow a fast whitening process without the pain associated with comparable treatments.

A WHITE SMILE IS NOTHING SHORT OF A CONFIDENT SMILE

  • PBM White  Carbimide peroxide level is LOW but efficiency is HIGH. The proprietary formulation allows higher efficiency due to interaction with the light energy.
  • The
    LOW peroxide level prevents sensitivity and pain associated with common
    whitening treatments and reduces tooth damage risks.

High Grade Device

  • High quality silicon device
  • Easy to use
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Special Proprietary Process

  • Gentle whitening formula gel
  • Whiter teeth in 10 days
  • Only 15 minutes a day. Can be done more than once a day.

PBM WHITE

A WHITE SMILE IS NOTHING SHORT OF A CONFIDENT SMILE

  • PBM White embraces the use of light technology to whitening smiles. Our unique gel removes years of stains caused by coffee, tea, wine, or smoking.
  • PBM White combines a unique 2 wave lengths technology and a proprietary gel formulation to  allow a fast whitening process without the pain associated with comparable treatments.

A WHITE SMILE IS NOTHING SHORT OF A CONFIDENT SMILE

  • PBM White  Carbimide peroxide level is LOW but efficiency is HIGH. The proprietary formulation allows higher efficiency due to interaction with the light energy.
  • The LOW peroxide level prevents sensitivity and pain associated with common
    whitening treatments and reduces tooth damage risks.

High Grade Device

  • High quality silicon device
  • Easy to use
  • Hands-free device

Special Proprietary Process

  • Gentle whitening formula gel
  • Whiter teeth in 10 days
  • Only 15 minutes a day. Can be done more than once per day.

PBM IMPLANT

Why Use PBM Implant

  • PBM Implant’s photobiomodulation anti inflammatory effect reduces pain significantly.
  • PBM Implant accelerates bone recovery. Implants are inserted quicker reducing the period with no tooth.
  • PBM Implant stimulates soft tissue and gums healing and regeneration significantly reducing risk of inflammation and pain post implant placement.
  • PBM Implant allows to treat patients that would not be candidates including smokers and patients with diabetes.

Flexible & comfortable mouthpiece

  • Standard Size mouthpiece with 46 LED’s
  • Decrease discomfort and pain

Flexible & comfortable mouthpiece

  • Portable hands-free device
  • Powered by a strong external battery

Faster Treatment treatment times

  • Decrease implant failure risk
  • Improve stability

Accelerate recovery

  • Improve bone recovery
  • Enhance gums health

PBM VIBE

Why Use PBM Vibe

  • PBM Vibe uses vibration and mechanical energy to improve your treatment with aligners
  • Vibration improves the aligners seating and therefore maximises the efficiency of your treatment.
  • Vibration also has a soothing effect and reduce pain during your orthodontic treatment.

Flexible & comfortable mouthpiece

  • Reduced discomfort and sensitivity
  • Comfortable and light weight
  • One 5-minute treatment

Faster Treatment treatment times

  • Optimal aligner seating
  •  Increased stability and retention after treatment
  • Light vibration energy to stimulate bones

PBM VIBE

Why Use PBM Vibe

  • Clear aligners are maximally efficient when they’re seated correctly, meaning the aligners are gripping the teeth properly.
  • Vibration mechanically improves aligners seating and efficiency.
  • Vibration triggers a biological response. It promotes bone remodeling via activation of nuclear factor-kappa B to stimulate osteoclastic bone resorption and allow faster tooth movement.
  • Vibration has a soothing effect. Reducing side effects improve patient’s satisfaction.

Flexible & comfortable mouthpiece

  • Reduced discomfort and sensitivity
  • Comfortable and light weight

Easy to Use

  • Portable hands-free device
  • Powered by a strong external battery

Faster Treatment treatment times

  • Optimal aligner seating
  •  Increased stability and retention after treatment

Gentle Therapy

  • PBM Vibe uses light vibration energy at 200 Hz
  • One 5-minute treatment per session

PBM IMPLANT

Why Use PBM Implant

  • Photobiomodulation stimulates mitochondrial activity which stimulates bone regeneration and blood flow.
  • PBM Implant improves bone structure that leads to faster implant loading and greater implant stability.
  • Better osseointegration enables more efficient bone grafting.
  • PBM Implant allows to treat patients that would not be candidates including smokers, patients with diabetes ….

Why Light Therapy

PBM Implant uses 680 nm near-infrared (NIR) light, which is similar to heat lamps, to deliver energy gently but directly to the bone and tissue around the implant body. Similar to plants and photosynthesis, the tissue can absorb this light energy and convert it to chemical energy, which stimulates the cells for faster bone and soft tissue regeneration and faster implant stability.

Flexible & comfortable mouthpiece

  • Standard Size mouthpiece with 46 LED’s
  • Decrease discomfort and pain

Flexible & comfortable mouthpiece

  • Portable hands-free device
  • Powered by a strong external battery

Faster Treatment treatment times

  • Cut treatment time by accelerating bone rejunevation
  • Improve stability

Gentle Therapy

  • 650nm wavelength low energy treatment
  • One 6-minute treatment per day per arch

PBM ORTHO

  • PBM Ortho is a non-invasive way to enhance a patient’s own healing ability by harnessing the power of light technology (photobiomodulation).
  • PBM Ortho is effective on any types of orthodonctics appliances including aligners or braces.
  • Photobiomodulation triggers a natural anti inflammatory response that has a deep pain relief effect during the treatment.
  • Enhanced biological activity improves your treatment efficiency.

Why Light Therapy

PBM Ortho uses 850 nm near-infrared (NIR) light, which is similar to heat lamps, to deliver energy gently but directly to the bone and tissue around the roots of the teeth. Similar to plants and photosynthesis, the tissue can absorb this light energy and convert it to chemical energy, which stimulates the cells for faster bone and soft tissue regeneration and faster tooth movement.

Flexible & comfortable mouthpiece

  • Standard Size mouthpiece with 42 LED’s
  • Extension Device for treating molars with 46 LED’s

Easy to Use

  • Portable hands-free device
  • Powered by a strong external battery

Faster Treatment treatment times

  • Change aligners every 3 days (down from 8.5 days)
  • Cut treatment time by 2.2 fold when used with braces

Gentle Therapy

  • PBM Ortho uses low levels of LED light
  • One 4-minute treatment per day per arch

PBM ORTHO

Why Light Therapy

PBM Ortho uses 850 nm near-infrared (NIR) light, which is similar to heat lamps, to deliver energy gently but directly to the bone and tissue around the roots of the teeth. Similar to plants and photosynthesis, the tissue can absorb this light energy and convert it to chemical energy, which stimulates the cells for faster bone and soft tissue regeneration and faster tooth movement.
  • PBM Ortho is a home device for patient designed to be used for aligners and fixed appliances treatment.
  • PBM Ortho is available in two sizes for molar treatment if necessary.
  • PBM Ortho use an 850nm wavelength for optimal effect.
  • Photobiomodulation effect stimulates mitochondrial activity. Increased activity triggers an anti-inflammatory natural response that reduces pain
  • Photobiomodulation activity also stimulates bone and improve elasticity leading to accelerating movement during treatment independently of the procedure.
  • Treatment time is 4 mins per arch.
  • Product is guaranteed 2 years from the time of first usage.

Flexible & comfortable mouthpiece

  • Standard Size mouthpiece with 42 LED’s
  • Extension Device for treating molars with 46 LED’s

Faster Treatment treatment times

  • Change aligners every 3 days (down from 8.5 days)
  • Cut treatment time by 2.2 fold when used with braces

Gentle Therapy

  • 850nm wavelength low energy treatment
  • One 4-minute treatment per day per arch

Dr Alan Kwong Hing

Chairman and Founder

the Founder of PBM Healing, graduated with his Doctor of Dental Surgery degree (with distinction) from the University of Western Ontario. He received the University Gold Medal and completed a concurrent master’s degree in Pathology. Dr. Al has earned multiple other degrees and received numerous awards, including the pre–Doctoral IADR Hatton award for his research on MRIs. He is a serial entrepreneur, had a diverse career as a solo dentist, and owned large multi-dental groups in Canada, the UK, and the US. He has owned dental labs and specialized orthodontic labs, a dental model company, and a company that manufactured orthodontic wires and accessories.

He was a KOL for NobelBiocare for many years and worked with the team to develop the NobelBiocare Replace Implant. He ran a mini dental residency to train dentists and their teams in dental implant surgery and restorative procedures.

He enjoys lecturing worldwide, focusing on applying Photobiomodulation in medicine and dentistry. Most notable is the application of PBM principles in the medical and dental devices that he has developed to help alleviate pain and enhance healing.

He also lectures on personal and practice development in his role as a Coach. He is a published author, most notably for the “E Myth Dentist” with Michael Gerber. His current book on General principles of Photobiomodulation is in its final draft stages.

Samuel Faveur

CEO

He is the CEO of PBM Healing,  a  Founding Partner, Director, and Chief Executive Officer of Mandarin Capital Ltd, a Hong Kong-based asset Management and advisory Company specialising in start ups and growth stage technology companies.

 Samuel began his career in 1999 as a research analyst for ING Barings in London before moving to ING Barings’ proprietary and market trading convertible bond desk. He was transferred to the Tokyo office in 2001 and, in 2003, joined Mizuho Securities in Hong Kong as Head of Asset Management. In this role, Samuel was tasked with setting up an internal hedge fund platform and managing two funds specializing in convertible bonds and volatility investments and additionally designed and implemented trading and operations infrastructures.

By the time Samuel left Mizuho Securities in 2010, he had held the title of Head of Asset Management and was registered Responsible Officer: Type 9. In 2011 Samuel briefly joined MF Global as Head of Derivatives with proprietary and client facilitation mandates. Before setting up Mandarin Capital Ltd in 2012, Sam held the position of Managing Director and Portfolio Manager at Richmond Asset Management.

Light Emitting Diode Mediated Photobiomodulation Therapy in Orthodontics – A Review of Contemporary Literature